Anti-IDH2 Rabbit pAb

ArtNr	PTM-6878
Hersteller	PTM Biolabs
Menge	100 ul
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Polyclonal
Format	Lyophilized powder
Applikationen	WB, IHC-P
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Konjugat/Tag	Unconjugated
Citations	Meng Wang, et al. Astragaloside IV protects renal tubular epithelial cells against oxidative stress-induced injury by upregulating CPT1A-mediated HSD17B10 lysine succinylation in diabetic kidney disease. PHYTOTHERAPY RESEARCH, 2024. https://onlinelibrary.wiley.com/doi/abs/10.1002/ptr.8298.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	ICD-M,IDP,NADP(+)-specific ICDH,Oxalosuccinate decarboxylase
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Uncategorized
Manufacturer - Targets	IDH2
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Signal Transduction, Cancer, Metabolism
Product description	IDH2 is one of three isocitrate dehydrogenases (IDH1-3) that catalyze the oxidative decarboxylation of isocitrate to produce CO2 and α-ketoglutarate (α-KG). These enzymes belong to two distinct subclasses that utilize either NAD or NADP+ as an electron acceptor. IDH2 is an NADP+-dependent isocitrate dehydrogenase expressed primarily in the mitochondria, where it also functions in the TCA cycle. Mutations in IDH2 or its cytoplasmic counterpart (IDH1) have been reported in glioblastoma multiforme, acute myeloid leukemia, and other malignancies. Research studies have shown that gain-of-function mutations in IDH2 can lead to the accumulation and secretion of the oncometabolite R-2-hydroxyglutarate (2HG) in cancer cells.
Purification Method	Protein A and immunogen affinity purified
Formula	PBS, Glycerol, BSA
PTM	Unmodified
Clonality	Polyclonal
Background	IDH2 is one of three isocitrate dehydrogenases (IDH1-3) that catalyze the oxidative decarboxylation of isocitrate to produce CO2 and α-ketoglutarate (α-KG). These enzymes belong to two distinct subclasses that utilize either NAD or NADP+ as an electron acceptor. IDH2 is an NADP+-dependent isocitrate dehydrogenase expressed primarily in the mitochondria, where it also functions in the TCA cycle. Mutations in IDH2 or its cytoplasmic counterpart (IDH1) have been reported in glioblastoma multiforme, acute myeloid leukemia, and other malignancies. Research studies have shown that gain-of-function mutations in IDH2 can lead to the accumulation and secretion of the oncometabolite R-2-hydroxyglutarate (2HG) in cancer cells.
Cellular Localization	Mitochondria

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Menge: 100 ul

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