Mouse anti-IL-8/CXCL8 [+Biotin]

Hersteller Raybiotech
Kategorie
Typ Antibody
Specific against Human
Isotype IgG1
Format Supplied as lyophilized purified antibody. It can be reconstituted with sterile PBS before use. Please avoid freeze-thaw cycles.
Applikationen ELISA
Menge 50 ug
Host Mouse
ArtNr RB-IP-01-111B-50
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Target Name
IL-8/CXCL8
Accession Number
NM_000584
Conjugate/Tag/Label
Biotin
Application notes:
ELISA (recommended work dilution= For Sandwich-based ELISA and membrane based assay, detecting level is up to 1pg/ml when it is used for capture), Western Blotting (recommended work dilution= 0.1-0.2 ug/ml)
Product Description
Interleukin-8, or IL-8, the prototypic member of the C-X-C, or alpha, family of chemokines, is a chemoattractant cytokine involved in the chemotaxis and activation of neutrophils. IL-8 expression has been correlated to a large number of chronic inflammatory diseases, including inflammatory bowel disease (IBD) and atherosclerosis. IL-8 is cleaved from a 99 amino acid precursor to a 72 amino acid, nonglycosylated, and biologically active protein. Whether IL-8 functions in vivo as a monomer or a hydrogen-bonded dimer has not yet been resolved. Two IL-8 receptors, designated IL-8RA and IL-8RB, have been described and share 77% sequence identity. Both are seven-transmembrane domain proteins (7TMD), similar to the G protein-coupled receptors, and, in addition to IL-8, serve as receptors for other members of the alpha and beta chemokine families.
Immunogen
Immunogen was recombinant protein derived from human IL-8. This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with the immunogen. The IgG fraction of tissue culture supernatant was purified by Protein G/A affinity chromatography.

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Menge: 50 ug
Lieferbar: In stock
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