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Human CellExp™ TFPI2, Human recombinant

Human CellExp™ TFPI2, Human recombinant

ArtNr	268-11082-1
Hersteller	Raybiotech
Menge	10 ug
Kategorie	Peptides & Proteins Recombinant Proteins
Typ	Proteins
Specific against	Human (Homo sapiens)
Host	Hamster - Armenian
Purity	>95% determined by SDS-PAGE
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	TFPI2,PP5,REF1
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Category	Recombinant Protein
Shipping Temperature	Gel Pack
Storage Conditions	The protein may be stored for 12 months at -20° C
Molecular Weight	This protein is fused with 6xHis tag at the N-terminus, has a calculated MW of 22.7 kDa. The predicted N-terminus is Asp 23. DTT-reduced Protein migrates as 26-32 kDa due to glycosylation.
Gene Symbols	TFPI2
Reconstitution	Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µ g/ml. Do not vortex. This solution can be stored at 2-8° C for up to 1 month. For extended storage, it is recommended to store at -20° C.
Endotoxin Level	<1 EU/ug by LAL method
Biological activity	Measured by its ability to inhibit trypsin cleavage of a fluorogenic peptide substrate, Mca - RPKPVE - Nval - WRK (Dnp) - NH2. The IC50 value is < 2.5 nM, as measured in 100uL reaction mixture containing 1.25 ng trypsin, 10 uM substrate, 50 mM Tris, 10 mM CaCl2, 0.15 M NaCl, 0.05% Brij-35, pH 7.5.
Introduction	Tissue Factor Pathway Inhibitor 2 (TFPI2), also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.
Country of Animal Origin	USA

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