Recombinant Mouse M-CSF

Hersteller Raybiotech
Kategorie
Typ Proteins
Specific against Mouse
Menge 10 ug
ArtNr 229-20305
eClass 6.1 34160400
eClass 9.0 42020190
Lieferbar
Short Description
Purified recombinant M-CSF expressed in E.coli
Introduction
M-CSF (Macrophage colony-stimulating factor) is a potent lineage restricted haematopoietic growth factor and member of the CSF family of hormone-like glycoproteins, which plays a key role in the regulation of cellular differentiation, proliferation, and the survival of blood monocytes, tissue macrophages and their progenitor cells.

Along with sRANKL/CD254/OPGL, M-CSF is essential for osteoclastogenesis, acting through the tyrosine kinase receptor c-fms (colony stimulating factor 1 receptor). A genetic defect in M-CSF is responsible for osteopetrosis in mice (op/op), which are severely deficient in mature macrophages and have a restricted capacity for bone remodelling.
Protein Name
M-CSF
Molecular Weight (kDa)
36.4kD (156 amino acid homodimer)
Purity
%98 by SDS PAGE and HPLC analysis
Concentration
ca.0.1mg/ml
Preservative
None present
Endotoxin Level
<1EU/ug
Protein Type
Recombinant Protein
Recommended Applications
Functional Assays
Biological activity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is < 1.0 ng/ml, corresponding to a specific activity of > 1 x 106 units/mg.
Reconstitution
Reconstitute with 100ul distilled water
Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. RayBiotech recommends that the vial is gently mixed after reconstitution.
Storage/stability
Prior to reconstitution store at +4° C.
After reconstitution store at -20° C.
Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. This protein may be stored for3 months from date of reconstitution.
Menge: 10 ug
Lieferbar: In stock
Listenpreis: 528,00 €
Preis: 528,00 €
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