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omega-Conotoxin MVIIA

omega-Conotoxin MVIIA

ArtNr	ALO-C-670-0.25mg
Hersteller	Alomone
CAS-Nr.	107452-89-1
Menge	0.25 mg
Quantity options	0.1 mg 0.25 mg 0.5 mg 10 mg 1 mg 50 ug 5 mg
Kategorie	Reagents & Chemicals Other Chemicals
Typ	Chemicals
Format	Lyophilized
Specific against	other
Purity	≥99% (HPLC)
Formula	Lyophilized from double distilled water (ddH2O). May contain TFA as a residual counter ion.
Sequence	CKGKGAKCSRLMYDCCTGSCRSGKC-NH<sub>2</sub>
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Non Antibodies
Manufacturer - Applications	Electrophysiology
Manufacturer - Category	Proteins
Manufacturer - Targets	CaV2.2 Ca2+ channel
Country of Origin	Israel
Shipping Temperature	The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture.
Storage Conditions	Storage as Solution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. - Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. - Storage after Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles.
Molecular Weight	2639.2 Da
Manufacturer - Format	Lyophilized
Short description	A Specific Blocker of CaV2.2 Channel
Description	SNX-111, Omega-conotoxin MVIIA, Ziconotide - A Specific Blocker of CaV2.2 Channel
Reconstitution	Centrifuge the vial (10, 000 × g for 5 minutes) before adding solvent to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Gently tap, tilt, and roll the vial to aid dissolution. Avoid vigorous vortexing; light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Specificity	A Specific Blocker of Ca_V2.2 Channel
PH	7, 4
UNSPSC	12352202
Origin	Conus magus (Magical cone)
Modifications	Disulfide bonds between: Cys¹-Cys¹⁶, Cys⁸-Cys²⁰ and Cys¹⁵-Cys²⁵ Cys²⁵ - C-terminal amidation
Effective Concentration	100 nM - 2 µM
Activity	ω-Conotoxin MVIIA specifically blocks N-type CaV channels1 and also inhibits K+-induced 3H-GABA release in the hippocampus in vivo2.
Solubility	Centrifuge the vial before adding solvent (10, 000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 µM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity.
Sterile endotoxin free	no
Bioassay tested	yes
Scientific Background	ω-Conotoxin MVIIA is a synthetic peptidyl toxin originally isolated from Conus magus snail venoM ω-Conotoxin MVIIA specifically blocks CaV2.2 (α1B, N-type) channels1. The effect of the toxin is modulated by CaVβ auxiliary subunit2 and by voltage (i.e. it is more potent for inactivated channels)3.ω-Conotoxin MVIIA inhibits K+-induced 3H-GABA release in hippocampus in vivo4. This effect was with high affinity (50% block, 200 nM). The toxin was used to inhibit synaptic transmission in several peripheral preparations5, 6, 7. The toxin binds with high affinity to rat neocortical membranes8. It blocked cloned CaV2.2 channels transiently expressed in tsa-2019 and in Xenopus oocytes3.The FDA recently approved Prialt (synthetic ω-Conotoxin MVIIA) to treat severe chronic pain in patients who are intolerant of or refractory to other treatments such as systemic analgesics or other pain medication such as opiates. This is the first ion channel blocker to be marketed for pain.

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ALO-C-670-0.25mg-safety-datasheet.pdf