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Halofuginone (Standard)

Halofuginone (Standard)

ArtNr	HY-N1584R-50mg
Hersteller	MedChem Express
CAS-Nr.	55837-20-2
Menge	50 mg
Quantity options	1 ea 100 mg 10 mg 25 mg 50 mg 5 mg
Kategorie	Reagents & Chemicals Standards, Ladders & Markers Other Standards
Typ	Standard
Specific against	other
Purity	99.73
Citations	[1]Tsuchida K, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247.\|[2]Keller TL, et al. Halofuginone and other Febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7.\|[3]Cui Z, et al. Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016 Sep;75(9):1714-21.\|[4]Tracy L McGaha, et al. Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts. J Invest Dermatol. 2002 Mar;118(3):461-70.\|[5]Pritesh P Jain, et al. Halofuginone, a Promising Drug for Treatment of Pulmonary Hypertension. Br J Pharmacol. 2021 Mar 10.
Smiles	O=C1N(CC(C[C@@H]2NCCC[C@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Alias	RU-19110 (Standard)
Versandbedingung	Raumtemperatur
Lieferbar
Manufacturer - Type	Reference Standards
Manufacturer - Targets	Calcium Channel; DNA/RNA Synthesis; Parasite; Reference Standards; Sodium Channel; TGF-beta/Smad
Shipping Temperature	Room Temperature
Storage Conditions	4°C, sealed storage, away from light and moisture
Molecular Weight	414.68
Product Description	Halofuginone (Standard) is the analytical standard of Halofuginone. This product is intended for research and analytical applications. Halofuginone (RU-19110), a Febrifugine derivative, is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated, receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria, anti-inflammatory, anti-cancer, anti-fibrosis effects[5].
Manufacturer - Research Area	Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
Manufacturer - Pathway	Anti-infection; Cell Cycle/DNA Damage; Membrane Transporter/Ion Channel; Neuronal Signaling; Others; Stem Cell/Wnt; TGF-beta/Smad

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Menge: 50 mg

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