Camostat Mesylate

RT

494, 52

White to off-white solid

Orally active, non-peptide proteolitic enzyme inhibitor with anti-trypsin and anti-plasmin activities, related structurally to gabexate. Protease inhibitor. Camostat mesilate is a serine protease inhibitor that inhibits plasmin, kallikrein, thrombin as well as trypsin, which attenuates pancreatic fibrosis.  It reduces weight gain and improves metabolism in obese rodent models.  It is in clinical use (in Japan) for pancreatitis. Camostat has been found to inhibit influenza virus replication in human tracheal epithelial cells and is also a direct prostasin inhibitor which may be useful in reducing sodium transport in cystic fibrosis. Additionally it has been shown to reduce infection of Calu-3 lung cells by SARS-CoV-2 (the coronavirus responsible for COVID-19) via inhibition of the serine protease TMPRSS2 required for viral spike protein priming.

Synonyms:
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic Acid 2-(Dimethylamino)-2-oxoethyl Ester Methanesulfonate; FOY 305; FOY-S 980; Foipan

CAS Number:
59721-29-8

Molecular Weight:
494.52

Molecular Formula:
C₂₁H₂₆N₄O₈S

Appearance:
White to off-white solid

Purity:
≥98%

Melting Point:
161-164°C

Solubility:
DMSO (Slightly), Methanol (Slightly)

Storage and Stability:
Store at 4°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.