GDP-L-fucose Disodium Salt

RT

633, 31

White to off-white powder

GDP-L-fucose diammonium salt is a synthetase inhibitor that has been shown to inhibit the synthesis of GDP-L-fucose. This compound is also known as 5, 6-dichloro-1, 2, 3, 4-tetrahydroisoquinoline and is a secondary metabolite of the bacterium Aerobacter aerogenes. The enzyme kinetic assay was used to determine the inhibition constant for this compound. It has been shown to be active against E. coli K-12 and S. subtilis in cell culture experiments. Inhibition of GDP-L-fucose synthesis by this compound leads to reduced bacterial growth, which may be due to its interference with cell surface carbohydrate attachment or its effects on other metabolic pathways such as glycolysis and nucleotide synthesis.

Synonyms:
Guanosine 5'-diphospho-b-L-fucose disodium salt; [[(2R, 3S, 4R, 5R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3, 4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R, 4R, 5R, 6S)-3, 4, 5-trihydroxy-6-methyloxan-2-yl] hydrogen phosphate disodium; 6-Deoxy-β-L-galactopyranosylguanosine 5′-diphosphate, GDP-Fuc disodium, GDP-fucose disodium

CAS No:
148296-47-3
Free Base: 15839-70-0

Molecular Formula:
C16H23N5O15P2Na2

Molecular Weight:
589.34

Appearance:
White to off-white powder

Purity:
≥98%

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.