Vergleich

Anti-CRYAB antibody

Hersteller St John's Laboratory
Kategorie
Typ Antibody Polyclonal
Specific against Human, Mouse, Rat
Isotype IgG
Applikationen WB
Menge 100ul
Host Rabbit
ArtNr STJ115651-100
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Clonality
Polyclonal
Conjugation
Unconjugated
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification
Affinity purification
Uniprot ID
P02511
Storage
Store at-20° C and avoid freeze-thaw cycles.
Description
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.
Gene ID
Gene symbol
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human CRYAB (NP_001876. 1).
Short Description
Rabbit polyclonal against CRYAB
Tissue specificity
Lens as well as other tissues. Expressed in myocardial tissue.
Cellular localization
Cytoplasm
Nucleus
Translocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing Speckles
Localizes At The Z-Bands And The Intercalated Disk In Cardiomyocytes
Molecular weight
Calculated: 20kDa. Observed: 20kDa
Dilution range
WB 1:500-1:2000
Alternative names
Anti-Alpha-Crystallin B Chain antibody
Anti-Alpha(B-Crystallin antibody
Anti-Heat Shock Protein Beta-5 antibody
Anti-Hspb5 antibody
Anti-Renal Carcinoma Antigen Ny-Ren-27 antibody
Anti-Rosenthal Fiber Component antibody
Anti-CRYAB CRYA2 HSPB5 antibody
Protein name
Alpha-Crystallin B Chain
Alpha(B-Crystallin
Heat Shock Protein Beta-5
Hspb5
Renal Carcinoma Antigen Ny-Ren-27
Rosenthal Fiber Component
Note
FOR RESEARCH USE ONLY (RUO).
Swiss port key

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Menge: 100ul
Lieferbar: In stock
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Lieferung vsl. bis 25.04.2024 

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