Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Isotype |
IgG |
Applikationen |
WB |
Menge |
100ul |
Host |
Rabbit |
ArtNr |
STJ115651-100 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P02511 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human CRYAB (NP_001876. 1). |
Short Description |
Rabbit polyclonal against CRYAB |
Tissue specificity |
Lens as well as other tissues. Expressed in myocardial tissue. |
Cellular localization |
CytoplasmNucleusTranslocates To The Nucleus During Heat Shock And Resides In Sub-Nuclear Structures Known As Sc35 Speckles Or Nuclear Splicing SpecklesLocalizes At The Z-Bands And The Intercalated Disk In Cardiomyocytes |
Molecular weight |
Calculated: 20kDa. Observed: 20kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Alpha-Crystallin B Chain antibodyAnti-Alpha(B-Crystallin antibodyAnti-Heat Shock Protein Beta-5 antibodyAnti-Hspb5 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-27 antibodyAnti-Rosenthal Fiber Component antibodyAnti-CRYAB CRYA2 HSPB5 antibody |
Protein name |
Alpha-Crystallin B ChainAlpha(B-CrystallinHeat Shock Protein Beta-5Hspb5Renal Carcinoma Antigen Ny-Ren-27Rosenthal Fiber Component |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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