Anti-CRYAB Antibody

Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.

CRYAB antibody
Alpha-crystallin B chain antibody
Alpha(B antibody
-crystallin antibody
Heat shock protein beta-5 antibody
HspB5 antibody
Renal carcinoma antigen NY-REN-27 antibody
Rosenthal fiber component antibody
CRYAB antibody
CRYA2 antibody
HSPB5 antibody

Unconjugated

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

CRYAB

IgG

For Research Use Only (RUO).

Store at -20C. Avoid freeze / thaw cycles.

Lens as well as other tissues