Antibodies

Anti-CRYAB Antibody

Hersteller St John's Laboratory
Kategorie
Typ Antibody
Specific against Human, Mouse, Rat
Applikationen WB
Menge 100ul
Host Rabbit
ArtNr STJ115651-100
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Description
Mammalian lens crystallins are divided into alpha, beta, and gamma families. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy. Alternative splicing results in multiple transcript variants.
Short Description
Rabbit polyclonal to CRYAB
Alternative names
CRYAB antibody
Alpha-crystallin B chain antibody
Alpha(B antibody
-crystallin antibody
Heat shock protein beta-5 antibody
HspB5 antibody
Renal carcinoma antigen NY-REN-27 antibody
Rosenthal fiber component antibody
CRYAB antibody
CRYA2 antibody
HSPB5 antibody
Clonality
Polyclonal
Conjugation
Unconjugated
Dilution range
WB 1:500 - 1:2000
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene id
Gene symbol
Immunogen
Recombinant protein of human CRYAB
Iso type
IgG
Molecular weight
20.159 kDa
Note
For Research Use Only (RUO).
Purification
Affinity purification
Storage instruction
Store at -20C. Avoid freeze / thaw cycles.
Swiss prot key
Tissue specificity
Lens as well as other tissues
Uniprot id
P02511

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Menge: 100ul
Lieferbar: In stock
Listenpreis: 287,50 €
Preis: 287,50 €
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