Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Isotype |
IgG |
Applikationen |
WB, IHC |
Menge |
50ul |
Host |
Rabbit |
ArtNr |
STJ24811-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
O75469 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. |
Gene ID |
|
Gene symbol |
|
Immunogen |
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human NR1I2 (NP_071285. 1). |
Short Description |
Rabbit polyclonal against NR1I2 |
Tissue specificity |
Expressed in liver, colon and small intestine. |
Cellular localization |
Nucleus |
Molecular weight |
Calculated: 39kDa/43kDa/45kDa/48kDa/49kDa/52kDa/53kDa. Observed: 49kDa |
Dilution range |
WB 1:500-1:2000 IHC 1:50-1:200 |
Alternative names |
Anti-Nuclear Receptor Subfamily 1 Group I Member 2 antibodyAnti-Orphan Nuclear Receptor Par1 antibodyAnti-Orphan Nuclear Receptor Pxr antibodyAnti-Pregnane X Receptor antibodyAnti-Steroid And Xenobiotic Receptor antibodyAnti-Sxr antibodyAnti-NR1I2 PXR antibody |
Protein name |
Nuclear Receptor Subfamily 1 Group I Member 2Orphan Nuclear Receptor Par1Orphan Nuclear Receptor PxrPregnane X ReceptorSteroid And Xenobiotic ReceptorSxr |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
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