Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Isotype |
IgG |
Applikationen |
WB |
Menge |
50ul |
Host |
Rabbit |
ArtNr |
STJ25022-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q03405 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-305 of human PLAUR (NP_002650. 1). |
Short Description |
Rabbit polyclonal against PLAUR |
Tissue specificity |
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
Cellular localization |
Cell MembraneCell ProjectionInvadopodium MembraneColocalized With Fap (Seprase) Preferentially At The Cell Surface Of Invadopodia Membrane In A Cytoskeleton-Integrin-And Vitronectin-Dependent MannerIsoform 1: Cell MembraneLipid-AnchorGpi-AnchorIsoform 2: Secreted |
Molecular weight |
Calculated: 31kDa/32kDa/36kDa. Observed: 36-72kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Urokinase Plasminogen Activator Surface Receptor antibodyAnti-U-Par antibodyAnti-Upar antibodyAnti-Monocyte Activation Antigen Mo3 antibodyAnti-Cd Antigen Cd87 antibodyAnti-PLAUR MO3 UPAR antibody |
Protein name |
Urokinase Plasminogen Activator Surface ReceptorU-ParUparMonocyte Activation Antigen Mo3Cd Antigen Cd87 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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