Manufacturer |
St John's Laboratory
|
Category |
|
Type |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Isotype |
IgG |
Applications |
WB |
Amount |
50ul |
Host |
Rabbit |
Item no. |
STJ25022-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Available |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q03405 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 23-305 of human PLAUR (NP_002650. 1). |
Short Description |
Rabbit polyclonal against PLAUR |
Tissue specificity |
Expressed in neurons of the rolandic area of the brain (at protein level). Expressed in the brain. |
Cellular localization |
Cell MembraneCell ProjectionInvadopodium MembraneColocalized With Fap (Seprase) Preferentially At The Cell Surface Of Invadopodia Membrane In A Cytoskeleton-Integrin-And Vitronectin-Dependent MannerIsoform 1: Cell MembraneLipid-AnchorGpi-AnchorIsoform 2: Secreted |
Molecular weight |
Calculated: 31kDa/32kDa/36kDa. Observed: 36-72kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Urokinase Plasminogen Activator Surface Receptor antibodyAnti-U-Par antibodyAnti-Upar antibodyAnti-Monocyte Activation Antigen Mo3 antibodyAnti-Cd Antigen Cd87 antibodyAnti-PLAUR MO3 UPAR antibody |
Protein name |
Urokinase Plasminogen Activator Surface ReceptorU-ParUparMonocyte Activation Antigen Mo3Cd Antigen Cd87 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.