Anti-Phospho-PI 3-kinase p8 Alpha (Y607) antibody

Unconjugated

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Store at-20° C, and avoid repeat freeze-thaw cycles.

PI 3-kinase p85alpha is a protein encoded by the PIK3R1 gene which is approximately 83, 5 kDa. PI 3-kinase p85alpha is localised to the cytoplasm, cytosol and nucleus. It is involved in RET signalling, the IL-2 pathway, downstream signalling of activated FGFR2, regulation of lipid metabolism and insulin signalling-generic cascades. It binds to activated protein-Tyr kinases, through its SH2 domain, and acts as an adapter in mediating the association of the p110 catalytic unit to the plasma membrane. It is necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. PI 3-kinase p85alpha isoform 2 and isoform 4 are present in skeletal muscle. Mutations in the PIK3R1 gene may result in Short syndrome and Agammaglobulinemia. STJ90925 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous PI 3-kinase p85alpha protein which only binds about Y607 when Y607 is phosphorylated.

PIK3R1

550-630 aa

Isoform 2 is expressed in skeletal muscle and brain, and at lower levels in kidney and cardiac muscle. Isoform 2 and isoform 4 are present in skeletal muscle (at protein level).

IF 1:50-200
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000

Phosphatidylinositol 3-Kinase Regulatory Subunit Alpha
Pi3-Kinase Regulatory Subunit Alpha
Pi3k Regulatory Subunit Alpha
Ptdins-3-Kinase Regulatory Subunit Alpha
Phosphatidylinositol 3-Kinase 85 Kda Regulatory Subunit Alpha
Pi3-Kinase Subunit P85-Alpha
Ptdins-3-Kinase Regulatory Subunit P85-Alpha

P85A_HUMAN