Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human, Mouse, Rat |
Isotype |
IgG |
Applikationen |
WB, ELISA |
Menge |
200ul |
Host |
Rabbit |
ArtNr |
STJ91548-200 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Uniprot ID |
P31749 |
Storage |
Store at-20° C, and avoid repeat freeze-thaw cycles. |
Concentration |
1 mg/ml |
Description |
Rabbit polyclonal to Akt1. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Synthesized peptide derived from human Akt around the non-phosphorylation site of T308. |
Immunogen region |
250-330 aa |
Short Description |
Rabbit polyclonal against Akt1 |
Tissue specificity |
Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. |
Cellular localization |
CytoplasmNucleusCell MembraneNucleus After Activation By Integrin-Linked Protein Kinase 1 (Ilk1)Nuclear Translocation Is Enhanced By Interaction With Tcl1aPhosphorylation On Tyr-176 By Tnk2 Results In Its Localization To The Cell Membrane Where It Is Targeted For Further Phosphorylations On Thr-308 And Ser-473 Leading To Its Activation And The Activated Form Translocates To The NucleusColocalizes With Wdfy2 In Intracellular Vesicles |
Molecular weight |
55 kDa |
Dilution range |
WB 1:500-1:2000ELISA 1:20000 |
Alternative names |
Anti-Rac-Alpha Serine/Threonine-Protein Kinase antibodyAnti-Protein Kinase B antibodyAnti-Pkb antibodyAnti-Protein Kinase B Alpha antibodyAnti-Pkb Alpha antibodyAnti-Proto-Oncogene C-Akt antibodyAnti-Rac-Pk-Alpha antibodyAnti-AKT1 PKB RAC antibody |
Protein name |
Rac-Alpha Serine/Threonine-Protein KinaseProtein Kinase BPkbProtein Kinase B AlphaPkb AlphaProto-Oncogene C-AktRac-Pk-Alpha |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
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