ArtNr |
STJ91548-200 |
Hersteller |
St John's Laboratory
|
Menge |
200 ug |
Kategorie |
|
Typ |
Antibody Polyclonal |
Format |
Liquid |
Applikationen |
WB, ELISA |
Specific against |
Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus) |
Host |
Rabbit |
Isotype |
IgG |
Konjugat/Tag |
Unconjugated |
ECLASS 10.1 |
32160702 |
ECLASS 11.0 |
32160702 |
UNSPSC |
12352203 |
Alias |
Anti-Rac-Alpha Serine/Threonine-Protein Kinase antibody, Anti-Protein Kinase B antibody, Anti-Pkb antibody, Anti-Protein Kinase B Alpha antibody, Anti-Pkb Alpha antibody, Anti-Proto-Oncogene C-Akt antibody, Anti-Rac-Pk-Alpha antibody, Anti-AKT1 PKB RAC antibody |
Similar products |
Anti-Rac-Alpha Serine/Threonine-Protein Kinase antibodyAnti-Protein Kinase B antibodyAnti-Pkb antibodyAnti-Protein Kinase B Alpha antibodyAnti-Pkb Alpha antibodyAnti-Proto-Oncogene C-Akt antibodyAnti-Rac-Pk-Alpha antibody
|
Lieferbar |
|
Storage Conditions |
Store at-20°C, and avoid repeat freeze-thaw cycles. |
Molecular Weight |
55 kDa |
Description |
Rabbit polyclonal to Akt1. |
Formulation |
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
Concentration |
1 mg/ml |
Purification |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Immunogen |
250-330 aa |
Tissue specificity |
Expressed in prostate cancer and levels increase from the normal to the malignant state (at protein level). Expressed in all human cell types so far analyzed. The Tyr-176 phosphorylated form shows a significant increase in expression in breast cancers during the progressive stages i.e. normal to hyperplasia (ADH), ductal carcinoma in situ (DCIS), invasive ductal carcinoma (IDC) and lymph node metastatic (LNMM) stages. |
Cellular localization |
Cytoplasm Nucleus Cell Membrane Nucleus After Activation By Integrin-Linked Protein Kinase 1 (Ilk1) Nuclear Translocation Is Enhanced By Interaction With Tcl1a Phosphorylation On Tyr-176 By Tnk2 Results In Its Localization To The Cell Membrane Where It Is Targeted For Further Phosphorylations On Thr-308 And Ser-473 Leading To Its Activation And The Activated Form Translocates To The Nucleus Colocalizes With Wdfy2 In Intracellular Vesicles |
Clonality |
Polyclonal |
Protein name |
Rac-Alpha Serine/Threonine-Protein Kinase Protein Kinase B Pkb Protein Kinase B Alpha Pkb Alpha Proto-Oncogene C-Akt Rac-Pk-Alpha |
Gene symbol |
AKT1 |
Dilution range |
WB 1:500-1:2000 ELISA 1:20000 |
Note |
For Research Use Only (RUO). |
Immunogen Region |
250-330 aa |
Short Description |
Rabbit polyclonal against Akt1 |
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