Anti-LDLR antibody

Polyclonal

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

P01130

The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.

LDLR

Rabbit polyclonal against LDLR

Calculated: 75kDa/76kDa/82kDa/90kDa/95kDa. Observed: 120kDa

Anti-Low-Density Lipoprotein Receptor antibody
Anti-Ldl Receptor antibody
Anti-LDLR antibody

FOR RESEARCH USE ONLY (RUO).