Anti-APOBEC3A Antibody

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.

APOBEC3A antibody
DNA dC->dU-editing enzyme APOBEC-3A antibody
A3A antibody
APOBEC3A antibody

Unconjugated

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

APOBEC3A

IgG

For Research Use Only (RUO).

Store at -20C. Avoid freeze / thaw cycles.

Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells, Highly expressed in keratinocytes and in periphery blood monocytes, Also detected in non-lymphoid tissues including lung and adipose tissues, Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia