Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human |
Isotype |
IgG |
Applikationen |
WB |
Menge |
50ul |
Host |
Rabbit |
ArtNr |
STJ114275-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
P31941 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human APOBEC3A (NP_663745. 1). |
Short Description |
Rabbit polyclonal against APOBEC3A |
Tissue specificity |
Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. |
Cellular localization |
NucleusCytoplasm |
Molecular weight |
Calculated: 21kDa/23kDa. Observed: 26kDa |
Dilution range |
WB 1:200-1:500 |
Alternative names |
Anti-Dna Dc->Du-Editing Enzyme Apobec-3a antibodyAnti-A3a antibodyAnti-Phorbolin-1 antibodyAnti-APOBEC3A antibody |
Protein name |
Dna Dc->Du-Editing Enzyme Apobec-3aA3aPhorbolin-1 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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