Anti-APOBEC3A Antibody

Hersteller St John's Laboratory
Kategorie
Typ Antibody
Specific against Human
Applikationen WB
Menge 50ul
Host Rabbit
ArtNr STJ114275-50
eClass 6.1 32160702
eClass 9.0 32160702
Lieferbar
Description
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene.
Short Description
Rabbit polyclonal to APOBEC3A
Alternative names
APOBEC3A antibody
DNA dC->dU-editing enzyme APOBEC-3A antibody
A3A antibody
APOBEC3A antibody
Clonality
Polyclonal
Conjugation
Unconjugated
Dilution range
WB 1:200 - 1:500
Formulation
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Gene id
Gene symbol
Immunogen
Recombinant protein of human APOBEC3A
Iso type
IgG
Molecular weight
23.012 kDa
Note
For Research Use Only (RUO).
Purification
Affinity purification
Storage instruction
Store at -20C. Avoid freeze / thaw cycles.
Swiss prot key
Tissue specificity
Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells, Highly expressed in keratinocytes and in periphery blood monocytes, Also detected in non-lymphoid tissues including lung and adipose tissues, Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia
Uniprot id
P31941

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Menge: 50ul
Lieferbar: In stock
Listenpreis: 235,71 €
Preis: 235,71 €
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