|
Hersteller |
St John's Laboratory
|
|
Kategorie |
|
|
Typ |
Antibody Polyclonal |
|
Specific against |
Human |
|
Isotype |
IgG |
|
Applikationen |
WB |
|
Menge |
50ul |
|
Host |
Rabbit |
|
ArtNr |
STJ114275-50 |
|
eClass 6.1 |
32160702 |
|
eClass 9.0 |
32160702 |
|
Lieferbar |
 |
| Clonality |
Polyclonal |
| Conjugation |
Unconjugated |
| Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Purification |
Affinity purification |
| Uniprot ID |
P31941 |
| Storage |
Store at-20° C and avoid freeze-thaw cycles. |
| Description |
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. |
| Gene ID |
|
| Gene symbol |
|
| Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-199 of human APOBEC3A (NP_663745. 1). |
| Short Description |
Rabbit polyclonal against APOBEC3A |
| Tissue specificity |
Expressed in peripheral leukocytes with higher expression in CD14-positive phagocytic cells. Highly expressed in keratinocytes and in periphery blood monocytes. Also detected in non-lymphoid tissues including lung and adipose tissues. Found at high levels in colorectal adenocarcinoma, Burkitt's lymphoma and chronic myelogenous leukemia. |
| Cellular localization |
NucleusCytoplasm |
| Molecular weight |
Calculated: 21kDa/23kDa. Observed: 26kDa |
| Dilution range |
WB 1:200-1:500 |
| Alternative names |
Anti-Dna Dc->Du-Editing Enzyme Apobec-3a antibodyAnti-A3a antibodyAnti-Phorbolin-1 antibodyAnti-APOBEC3A antibody |
| Protein name |
Dna Dc->Du-Editing Enzyme Apobec-3aA3aPhorbolin-1 |
| Note |
FOR RESEARCH USE ONLY (RUO). |
| Swiss port key |
|
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