Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Human |
Isotype |
IgG |
Applikationen |
WB, IF |
Menge |
100ul |
Host |
Rabbit |
ArtNr |
STJ117856-100 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
Q9NX02 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
This gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). Members of this gene family are thought to be important regulators of immune responses. This gene product interacts with components of the IkB kinase (IKK) complex, and can regulate both caspase-1 and NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) activity. The pyrin domain is necessary and sufficient for suppression of NF-kB activity. An allelic variant (rs147585490) has been found that is incapable of blocking the transcriptional activity of NF-kB. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Gene ID |
|
Gene symbol |
|
Immunogen |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human NLRP2 (NP_060322. 1). |
Short Description |
Rabbit polyclonal against NLRP2 |
Tissue specificity |
Expressed at high levels in lung, placenta and thymus and at lower levels in ovary, intestine and brain. |
Cellular localization |
Cytoplasm |
Molecular weight |
Calculated: 96kDa/117kDa/118kDa/120kDa. Observed: 121kDa |
Dilution range |
WB 1:500-1:2000 IF 1:50-1:200 |
Alternative names |
Anti-Nacht-Lrr And Pyd Domains-Containing Protein 2 antibodyAnti-Nucleotide-Binding Site Protein 1 antibodyAnti-Pyrin Domain And Nacht Domain-Containing Protein 1 antibodyAnti-Pyrin-Containing Apaf1-Like Protein 2 antibodyAnti-NLRP2 NALP2 NBS1 PAN1 PYPAF2 antibody |
Protein name |
Nacht-Lrr And Pyd Domains-Containing Protein 2Nucleotide-Binding Site Protein 1Pyrin Domain And Nacht Domain-Containing Protein 1Pyrin-Containing Apaf1-Like Protein 2 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
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