Hersteller |
St John's Laboratory
|
Kategorie |
|
Typ |
Antibody Polyclonal |
Specific against |
Mouse, Rat |
Isotype |
IgG |
Applikationen |
WB |
Menge |
50ul |
Host |
Rabbit |
ArtNr |
STJ114223-50 |
eClass 6.1 |
32160702 |
eClass 9.0 |
32160702 |
Lieferbar |
|
Clonality |
Polyclonal |
Conjugation |
Unconjugated |
Formulation |
PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification |
Affinity purification |
Uniprot ID |
O15105 |
Storage |
Store at-20° C and avoid freeze-thaw cycles. |
Description |
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. |
Gene ID |
|
Gene symbol |
|
Immunogen |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMAD7 (NP_005895. 1). |
Short Description |
Rabbit polyclonal against SMAD7 |
Tissue specificity |
Ubiquitous with higher expression in the lung and vascular endothelium. |
Cellular localization |
NucleusCytoplasmInteraction With Nedd4l Or Rnf111 Induces Translocation From The Nucleus To The CytoplasmTgf-Beta Stimulates Its Translocation From The Nucleus To The CytoplasmPdpk1 Inhibits Its Translocation From The Nucleus To The Cytoplasm In Response To Tgf-Beta |
Molecular weight |
Calculated: 23kDa/46kDa. Observed: 46kDa |
Dilution range |
WB 1:500-1:2000 |
Alternative names |
Anti-Mothers Against Decapentaplegic Homolog 7 antibodyAnti-Mad Homolog 7 antibodyAnti-Mothers Against Dpp Homolog 7 antibodyAnti-Mothers Against Decapentaplegic Homolog 8 antibodyAnti-Mad Homolog 8 antibodyAnti-Mothers Against Dpp Homolog 8 antibodyAnti-Smad Family Member 7 antibodyAnti-Smad 7 antibodyAnti-Smad7 antibodyAnti-Hsmad7 antibodyAnti-SMAD7 MADH7 MADH8 antibody |
Protein name |
Mothers Against Decapentaplegic Homolog 7Mad Homolog 7Mothers Against Dpp Homolog 7Mothers Against Decapentaplegic Homolog 8Mad Homolog 8Mothers Against Dpp Homolog 8Smad Family Member 7Smad 7Smad7Hsmad7 |
Note |
FOR RESEARCH USE ONLY (RUO). |
Swiss port key |
|
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