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Anti-SMAD7 antibody

Anti-SMAD7 antibody

Manufacturer	St John's Laboratory
Category	Antibodies Western Blot Primary Antibodies
Type	Antibody Polyclonal
Specific against	Mouse, Rat
Isotype	IgG
Applications	WB
Amount	50ul
Host	Rabbit
Item no.	STJ114223-50
eClass 6.1	32160702
eClass 9.0	32160702
Available
Clonality	Polyclonal
Conjugation	Unconjugated
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification	Affinity purification
Uniprot ID	O15105
Storage	Store at-20° C and avoid freeze-thaw cycles.
Description	The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Gene ID	4092
Gene symbol	SMAD7
Immunogen	A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMAD7 (NP_005895. 1).
Short Description	Rabbit polyclonal against SMAD7
Tissue specificity	Ubiquitous with higher expression in the lung and vascular endothelium.
Cellular localization	Nucleus Cytoplasm Interaction With Nedd4l Or Rnf111 Induces Translocation From The Nucleus To The Cytoplasm Tgf-Beta Stimulates Its Translocation From The Nucleus To The Cytoplasm Pdpk1 Inhibits Its Translocation From The Nucleus To The Cytoplasm In Response To Tgf-Beta
Molecular weight	Calculated: 23kDa/46kDa. Observed: 46kDa
Dilution range	WB 1:500-1:2000
Alternative names	Anti-Mothers Against Decapentaplegic Homolog 7 antibody Anti-Mad Homolog 7 antibody Anti-Mothers Against Dpp Homolog 7 antibody Anti-Mothers Against Decapentaplegic Homolog 8 antibody Anti-Mad Homolog 8 antibody Anti-Mothers Against Dpp Homolog 8 antibody Anti-Smad Family Member 7 antibody Anti-Smad 7 antibody Anti-Smad7 antibody Anti-Hsmad7 antibody Anti-SMAD7 MADH7 MADH8 antibody
Protein name	Mothers Against Decapentaplegic Homolog 7 Mad Homolog 7 Mothers Against Dpp Homolog 7 Mothers Against Decapentaplegic Homolog 8 Mad Homolog 8 Mothers Against Dpp Homolog 8 Smad Family Member 7 Smad 7 Smad7 Hsmad7
Note	FOR RESEARCH USE ONLY (RUO).
Swiss port key	SMAD7_HUMAN

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50ul

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Delivery expected until 6/6/2024