Anti-CDKN1B antibody (1-198) (STJ115573)

Store in a freezer at-20°C and avoid freeze-thaw cycles.

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

Lot specific

Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CDKN1B (NP_004055. 1).

Nucleus
Cytoplasm
Endosome
Nuclear And Cytoplasmic In Quiescent Cells
Akt-Or Rsk-Mediated Phosphorylation On Thr-198
Binds 14-3-3
Translocates To The Cytoplasm And Promotes Cell Cycle Progression
Mitogen-Activated Uhmk1 Phosphorylation On Ser-10 Also Results In Translocation To The Cytoplasm And Cell Cycle Progression
Phosphorylation On Ser-10 Facilitates Nuclear Export
Translocates To The Nucleus On Phosphorylation Of Tyr-88 And Tyr-89
Colocalizes At The Endosome With Snx6
This Leads To Lysosomal Degradation

Cyclin-Dependent Kinase Inhibitor 1b
Cyclin-Dependent Kinase Inhibitor P27
P27kip1

WB:1:500-1:1000
IF/ICC:1:50-1:100
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.

Recombinant fusion protein containing a sequence corresponding to amino acids 100-198 of human CDKN1B/p27KIP1 (NP_004055.1).