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MK-571 sodium

MK-571 sodium

ArtNr	TMO-T3148-10mM
Hersteller	TargetMol
CAS-Nr.	115103-85-0
Menge	10 mM x 1 mL (in DMSO)
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mL 25 mg 50 mg 5 mg
Kategorie	Reagents & Chemicals Molecules
Typ	Molecules
Specific against	other
Citations	1. Thivierge M, et al. J Immunol Res. 2015;2015:384780.
Smiles	[Na+].CN(C)C(=O)CCSC(SCCC([O-])=O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	Verlukast sodium, L-660711, MK571, MK-571 sodium salt, Propanoic acid, L-660711 sodium salt, L-660711 (sodium salt)
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Targets	Leukotriene Receptor\|\|\|LTR
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	537, 07
Description	MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics, and their conjugates. MK-571 sodium can inhibit the synthesis of K-4′-O-GlcA (19.7 μM). MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol sulphates and glucuronides by Caco-2 cells. MK-571 sodium significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4′-O-glucuronide was competitively inhibited. In addition to inhibiting MRP2, MK571 is a potent inhibitor of enterocyte phase-2 conjugation.
Bioactivity	MK-571 is a selective, orally active CysLT1 receptor(Cysteinyl leukotriene receptor) antagonist. MK571 is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor and has been widely used to demonstrate the role of Mrp2 in the cellular efflux of drugs, xenobiotics and their conjugates. The estimated Ki for inhibition of the synthesis of K-4?-O-GlcA by MK571 is 19.7 uM. MK571 dose-dependently inhibits the intracellular biosynthesis of all flavonol glucuronides and sulphates by Caco-2 cells. MK571 significantly inhibits phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-4?-O-glucuronide was competitively inhibited. These data show that MK571, in addition to inhibiting MRP2, is a potential inhibitor of enterocyte phase-2 conjugation.
Pathways	GPCR/G Protein\|\|\|Immunology/Inflammation
Receptor	CysLTR1

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Menge: 10 mM x 1 mL (in DMSO)

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