ML240

p97

-20

ML240 is a selective, ATP-competitive p97 inhibitor.

ML240 is a selective, ATP-competitive p97 inhibitor with IC50 values of 100 nM. target : p97 IC 50: 100 nM In vitro: ML240 potently stimulated accumulation of LC3-II within minutes, inhibited cancer cell growth, and rapidly mobilized the executioner caspases 3 and 7. The behavior of ML240 suggests that disruption of the protein homeostasis function of p97 leads to more rapid activation of apoptosis than is observed with a proteasome inhibitor. Meanwhile ML240 has broad antiproliferative activity toward the NCI-60 panel of cancer cell lines.