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PF-3758309 hydrochloride

PF-3758309 hydrochloride

ArtNr	TMO-T4230-200mg
Hersteller	TargetMol
CAS-Nr.	1279034-84-2
Menge	200 mg
Quantity options	100 mg 10 mM x 1 mL (in DMSO) 10 mg 1 mL 1 mg 200 mg 25 mg 2 mg 50 mg 5 mg
Kategorie	Oncology Neuroscience Targets for Rodent Neurosciences Reagents & Chemicals Molecules By Organ Lung Cancer
Typ	Molecules
Specific against	other
Citations	1. Briz V, Baudry M. Estrogen Regulates Protein Synthesis and Actin Polymerization in Hippocampal Neurons through Different Molecular Mechanisms. Front Endocrinol (Lausanne). 2014 Feb 25;5:22. doi: 10.3389/fendo.2014.00022. eCollection 2014. PubMed PMID: 24611062; PubMed Central PMCID: PMC3933789.
Smiles	Cl.CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Alias	PF-03758309 hydrochloride
Versandbedingung	Gekühlt
Lieferbar
Manufacturer - Targets	Apoptosis\|\|\|PAK
Shipping Temperature	cool pack
Storage Conditions	-20°
Molecular Weight	527, 08
Description	PF-3758309 hydrochloride (PF-03758309 hydrochloride) , is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PF-3758309 hydrochloride binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.
Bioactivity	PF-3758309, also known as PF-03758309, is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.
Pathways	Cytoskeletal Signaling\|\|\|Apoptosis
Receptor	PAK4; PAK1; PAK6; PAK5; PAK3

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