Astragalin

NF-κB|||Apoptosis

-20

Astragalin (Kaempferol 3-O-glucoside) is a biologically active natural flavonoid. It has a variety of pharmacological properties, including antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and cardioprotective properties.

1. Astragalin may be a potential agent in the treatment of osteoarthritis. 2. Astragalin can be effective in allaying ROS-promoted bronchial fibrosis through inhibiting autophagosome formation in airways. 3. Astragalin ameliorates oxidative stress-associated epithelial eosinophilia and apoptosis through disturbing TLR4-PKCbeta2-NADPH oxidase-responsive signaling. 4. Astragalin exerts anti-inflammatory properties possibly via the inactivation of TLR4-mediated NF-kappaB and mitogen-activated protein kinases signaling pathways in LPS-stimulated mMECs. 5. Astragalin exerts anti-inflammatory properties in LPS-mediated mastitis, possibly through inhibiting inhibition of the NF-kappaB signaling pathway, which mediates the expression of pro-inflammatory cytokines.