CD146 (Cell Surface Glycoprotein MUC18, Cell Surface Glycoprotein P1H12, Melanoma Cell Adhesion Molecule, Melanoma-associated Antigen A32, Melanoma-associated Antigen MUC18, S-endo 1 Endothelial-associated Antigen, MCAM,

Antibodies / Antibodies-CD Markers

Blue Ice

Affinity Purified

30021010

CD146 is a 118kD integral transmembrane glycoprotein, also known as MUC18, S-Endo, MCAM, and Mel-CAM (melanoma cell adhesion molecule). It belongs to the immunoglobulin superfamily. CD146 is expressed on melanoma cells, epithelial cells, endothelial cells, fibroblasts, activated T cells, multipotent mesenchymal stromal cells, and activated keratinocytes. CD146 mediates heterophilic cell adhesion and regulates monocyte transendothelial migration. The ligand of CD146 remains to be identified.

Applications:
Suitable for use in Flow Cytometry. Other applications not tested.

Recommended Dilutions:
Flow Cytometry: ≤0.5ug/10e5 cells in 100ul with immunofluorescent staining.
Optimal dilutions to be determined by the researcher.

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.