BU 224 Hydrochloride

RT

233, 7

Supplied as a white solid

High affinity ligand for the imidazoline I2 binding site (Ki = 2.1 nM). Putative I2 antagonist; antagonizes the effects of imidazoline ligands on morphine antinociception. Produces ipsiversive rotational behavior in rats with a full 6-OHDA lesion of the nigrostriatal tract.

CAS No:
205437-64-5

Solubility:
Soluble to 10mM in DMSO

TLC Conditions:
Dichloromethane:Methanol [10:1] Rf=0.18

Melting Point:
≥300°C

Method for Determining Identity:
Proton NMR Spectroscopic Analysis

Elemental Analysis
Calculated: %C: 61.67, %H: 5.14,
%N: 17.99

Storage and Stability:
Stored at RT. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Store with dessicants.