RANKL, Soluble, Recombinant, Mouse, Fc (TRANCE, ODF, OPGL, TNFSF11, CD254)

Molecular Biology / MB-Growth Factors-RANK

4°C/-20°C

Highly Purified

30021019

RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. Important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. RANKL plays an important role in the progression of Breast cancer.

Biological Activity:
Induces osteoclastogenesis of bone marrow-derived macrophages.

Sequence:
Mouse RANKL (aa 157-316) is fused to at the N-terminus to the Fc portion of human IgG1.

Specifcity:
Binds to mouse RANK.

Storage and Stability:
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.