GW1929

RT

495, 6

Supplied as an off-white to yellow crystalline solid.

Potent and subtype-selective (>1000-fold) PPARgamma agonist. Angiogenesis and apoptosis inhibitor. Anti-inflammatory. Anti-hyperglycemic and anti-hyperlipidemic agent. GW1929 is an antidiabetic; the glucose-lowering effect in rats is 100-fold more potent than that of troglitazone.

Synonyms:
N-(2-Benzoylphenyl)-L-tyrosine PPARγ Agonist; (2S)-((2-Benzoylphenyl)amino-3-[4-[2-(methylpyridin-2-ylamino)ethoxy]phenyl]propionic acid

CAS Number:
196808-24-9

Molecular Weight:
495.6

Molecular Formula:
C30H29N3O4

Solubility:
DMSO or methanol

Appearance:
Supplied as an off-white to yellow crystalline solid.

Purity:
≥98% (NMR)

Storage and Stability:
May be stored at 4°C for short-term only. Protect from light. Stable for 12 months after receipt when stored at -20°C. Store solutions at -20°C in the dark. For maximum recovery of product, centrifuge the original vial prior to removing the cap.