4-Methylumbelliferyl 2-Acetamido-2-deoxy-b-D-glucopyranoside (GlcNAc1-b-4MU)

RT

379, 36

White to off-white powder

Fluorogenic substrate used for the assay of b-Acetylglucosaminidase. A fluorogenic substrate used for the diagnosis of GM2 gangliosidoses in leukocytes. Genetic defects in human b-hexosaminidase isozymes (Hex A & Hex B) result in various clinical and biochemical types of GM2 gangliosidosis. They include Tay Sachs disease, Sandhoff disease and other forms.

Synonyms:
4-Methylumbelliferyl N-acetyl-b-D-glucosaminide; 4-MU-GlcNAc; M3C; GlcNAc-b-4MU

CAS No:
37067-30-4

Molecular Formula:
C₁₈H₂₁NO₈

Molecular Weight:
379.36

Appearance:
White to off-white powder

Purity:
≥98% (HPLC)

Identity (FT-IR):
Conforms to structure

Melting Point:
212-214°C

Specific Optical Rotation [α]D20 (c=1, pyridine):
-28 to -32°

Fluorescence:
max. Abs. l = 325nm, max. Em. l = 378nm

Free 4-MU:
≤0.01%

Water (Karl Fischer):
≤1%

Solubility:
Methanol, Warm Water , DMF

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.