7-Deazaguanosine

Biochemicals / Biochem-Nucleotides, Derivatives

4°C

Highly Purified

7-Deazaguanosine is a low energy analog of guanosine that has been shown to be activated by trifluoroacetic acid, which is a chemical reagent that can be used for the activation of nucleosides. 7-Deazaguanosine is used in the treatment of human serum and urine viruses such as hepatitis B virus, herpes simplex virus, and cytomegalovirus. The compound has also been shown to have receptor agonism activity on toll-like receptors. 7-Deazaguanosine has been shown to have antiviral effects against HIV and influenza A (H1N1). 7-Deazaguanosine binds at the viral receptor site and blocks the entry process into cells. This drug also stimulates macrophages to produce cytokines, which are proteins that regulate immune responses.

Synonyms:
2-Amino-7-(ß-D-ribofuranosyl[3, 2-d]pyrimidin-4-one; 2-Amino-1, 7-dihydro-7-β-D-ribofuranosyl-4H-pyrrolo[2, 3-d]pyrimidin-4-one

CAS No:
62160-23-0

Molecular Formula:
C11H14N4O5

Molecular Weight:
282.25

Purity:
≥98% (TLC)

Appearance:
White to off-white powder

Identity (1H NMR):
Conforms to reference

Melting Point:
>250°C dec (lit)

Storage and Stability:
Store at 4ºC. Product is stable for 12 months after receipt.