Fasudil, Monohydrochloride Salt

Blue Ice

327, 83

White to off-white powder

The monohydrochloride salt is the form used to prepare formulations of this drug for clinical use. Note that the solubility properties of the mono- and di-HCl salts are different. Kinase inhibitor; has antivasospastic properties.

Synonyms:
5-(1, 4-Diazepan-1-ylsulfonyl)isoquinoline monohydrochloride; Fasudil hydrochloride; Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1, 4-diazepine monohydrochloride

CAS No:
105628-07-7

Molecular Formula:
C14H17N3O2S•HCl

Molecular Weight:
327.83

Appearance:
White to off-white powder

Purity (HPLC/TLC):
≥99%

Solubility:
Very soluble in water, up to about 175mg/ml ; soluble in DMSO up to about 10mg/ml; not soluble in ethanol; pH of a 2% sloution is about 5.5-6; addition of an aqueous solution of this monohydrochloride salt into a buffer solution may significantly alter its solubility.

Storage and Stability:
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.