Pancreatin, Porcine Pancreas

Molecular Biology / MB-Enzymes

-20°C

Supplied as a yellow to tan powder. Contains lactose or sucrose as extender (sucrose may contain up to 3.25% starch.)

Hydrolyzes starch into dextrins and sugar Pancreatin from porcine pancreas is used in the treatment of steatorrhea by lipase supplementation therapy and for pancreatic diabetes. It is also used in the removal of formalin-fixed tissues from arterial grafts without causing damage in fiber integrity. Further, it finds uses in contact lenses. In addition to this, it hydrolyzes starch into dextrins and sugar. It is also used to treat conditions responsible for deficiency in pancreatic secretions, such as surgical pancreatectomy, pancreatitis and cystic fibrosis.

EC No:
232-468-9

CAS No:
8049-47-6

Source:
Porcine pancreas

Appearance:
Yellow to tan powder. Contains lactose or sucrose as extender (sucrose may contain up to 3.25% starch.)

Purity:
Contains many enzymes, including amylase, trypsin, lipase, ribonuclease and protease. The National Formulary (N.F.) and the U.S. Pharmacopeia (USP) specify amylase, protease and lipase only.

Loss on Drying:
≤1%

Fat:
≤1%

Amylase:
≥2units/mg

Lipase:
≥2units/mg

Protease:
≥2units/mg

Unit Definition:
Pancreatin will convert not less than 25 times its weight of potato starch into soluble carbohydrates in 5 minutes in water at 40°C, will digest not less than 25 times its weight of casein in 60 minutes at pH 7.5 at 40°C and will release not less than 2 microequivalents of acid per min per mg pancreatin from olive oil at pH 9.0 at 37°C.

Solubility:
Soluble in water. Insoluble in alcohol and ether.

Storage and Stability:
Lyophilized powder is stable for 6 months after receipt at -20°C.