In Vivo Grade Recombinant Anti-mouse PD-L1 Rat IgG2b Kappa Monoclonal Antibody (Clone 10F.9G2.1)

immunohistochemistry (IHC), Flow Cytometry (FC), and various in vitro and in vivo functional assays.

<5% Determined by SECP

The rat anti-mouse PD-L1 monoclonal antibody 10F.9G2 (rat IgG2b kappa) reacts with the mouse PD-L1 protein (programmed death ligand-1, B7-H1 or CD274), a member of the B7 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD-1 and anti-mouse PD-L1 antibodies which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The 10F.9G2 monoclonal antibody blocks the binding of the mouse PD-L1 protein to the mouse PD-1 protein.

mouse PD-L1 cDNA and mouse PD-L1 CHO transfectants

1×PBS pH 7.0