Lymphoid Enhancer Binding Factor 1 (LEF1) Antibody

Lymphoid Enhancer Binding Factor 1 (LEF1)

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

Lymphoid Enhancer Binding Factor 1 (LEF1) Antibody is a Rabbit Polyclonal antibody for the detection of LEF1.

Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity). Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.

LEF1

Purified by immunogen affinity chromatography.

153245