FBXO32 Antibody

FBXO32 Antibody is a Rabbit Polyclonal antibody against FBXO32. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Image Legend: Fig. 1. Western blot analysis of extracts of various cell lines, using FBXO32 antibody. Fig. 2. Immunohistochemistry of paraffin-embedded human colon cancer tissue using FBXO32 antibody.

Unconjugated

Affinity purified.

Q969P5

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

This product is for research use only.