TLR4 Polyclonal Antibody

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC-P (1:200-1:500).

Liquid solution

PBS, pH 7.4, containing 0.02% Sodium Azide as preservative and 50% Glycerol.

Gel pack with blue ice.

The protein encoded by TLR4 (toll like receptor 4) is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in TLR4 have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for TLR4.

The antibody detects endogenous TLR4 protein.