Anti-NFATc1 (clone AT1C3)

Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1(NFATc1) is a component of the nuclear factor of activated T cells DNA-binding transcription complex which consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. This protein plays a main role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription and functions as a major molecular target for the immunosuppressive drugs such as cyclosporine A. NFATc1 is expressed in most human primary lymphocytes and mature human T- and B-cell neoplasms.

Purified, in Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide.

Can be stored at +4C. For long term storage, aliquot and store at -20C. Avoid repeated freezing and thawing cycles.

0.1 mg/ml

Transcription &, Translation