Anti-Heat shock protein 60, HSP60

Heat shock protein 60 (HSP60) in the matrix of mitochondria is essential for the folding and assembly of newly imported proteins. Hsp60 belongs to a class of structurally related chaperonins found in organelles of endosymbiotic origin and in the bacterial cytosol. Members of the chaperonin class include the Escherichia coli, groEL protein and the Rubisco subunit-binding protein of chloroplasts. In both prokaryotic and eukaryotic systems, synthesis of these proteins is induced in response to stresses, such as heat shock. Under normal physiological conditions, HSP60 is a 60 KD oligomer composed of monomers that form a complex arranged as two stacked heptameric rings.1 HSP60 may be a very useful marker for patients with superficial bladder carcinoma and may be used for predicting disease progression. And low HSP60 expression levels may be usable as a prognostic marker to identify patients for whom local treatment would be insufficient. HSP60 also linked to diabetes, cancer and certain types of immunological disorders.

Purified, in TBS (pH7.4), 0.5% BSA, 25% Glycerol and 0.05% Sodium Azide.

Store at 2-8C (Short Term). Aliquot and store at -20C for long term. Avoid repeated freeze and thaw cycles.

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