Anti-Plet-1

The 33A10-defined antigen is the orphan protein, Placenta expressed transcript (Plet)-1. Biochemical data indiCated that Plet-1 is a glycosylphosphatidylinositol-anchored glycoprotein with N-linked carbohydRates in addition to other posttranslational modifiCations. Plet-1 is a a recently identified protein that as of yet has no known function and is not associated with any one family of proteins. Plet-1 is used as a cell surface marker present on stem/progenitor epithelial cells and in a number of tissues including thymus and skin, and on epithelial cell types in mammary gland, prostate, and pancreas.

33A10 reactivity is identified in the developing Mouse mammary gland, in the bronchioles of the lung, the salivary glands and the skin. Plet-1 is a product specific for Keratinocytes undergoing terminal trichilemmal differentiation in the hair follicle and is expressed at the plasma membranes.

33A10 is a Rat IgG2b monoclonal antibody derived by fusion of SP2/0 Mouse myeloma cells with spleen cells of Sprague-Dawley Rats immunized with Mouse mammary tumor cells.