Anti-CDC25A

The human CDC25 tyrosine phosphatases trigger activation of CDC2 by removing inhibitory phosphate from tyrosine and threonine residues of the cyclin-dependent kinases.The genes encoding these phosphatases are suspected of being potential oncogenes because of their role in promoting cell division. Three human CDC25 genes have been identified: CDC25A, CDC25B , and CDC25C . The CDC25A gene is mapped to 3p21 .in rodent cells, human CDC25A or CDC25B but not CDC25C phosphatases cooperate with either the gly12-to-val mutation of the HRAS gene or loss of RB1 in oncogenic focus formation.

Lyophilized

2-8C. For long term -20C after reconstitution.

• 1. Demetrick, D. J., Beach, D. H.Chromosome mapping of human CDC25A and CDC25B phosphatases.Genomics 18: 144-147, 1993.
• 2. Galaktionov, K., Lee, A. K., Eckstein, J., Draetta, G., Meckler, J., Loda, M., Beach, D.CDC25 phosphatases as potential human oncogenes.Science 269: 1575-1577, 1995.

Immunogen affinity purified.