Anti-HSD17B4

ArtNr	ARP-10-P1727
Hersteller	American Research Products
Menge	100 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Polyclonal
Specific against	other
Citations	1. Green, V. L., Speirs, V., Landolt, A. M., Foy, P. M., Atkin, S. L.17-beta-hydroxysteroid dehydrogenase type 1, 2, 3, and 4 expression and enzyme activity in human anterior pituitary adenomas.J. Clin. Endocr. Metab. 84: 1340-1345, 1999.2. Jiang, L. L., Miyazawa, S., Souri, M., Hashimoto, T.Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.J. Biochem. 121: 364-369, 1997.3.Leenders, F., Dolez, V., Begue, A., Moller, G., Gloeckner, J., de Launoit, Y., Adamski, J.Structure of the gene for the human 17-beta-hydroxysteroid dehydrogenase type IV.Mammalian Genome 9: 1036-1041, 1998.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Lieferbar
Description	Rabbit IgG polyclonal antibody for UMAN Unreviewed (HSD17B4) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background	The HSD17B4 gene encodes an enzyme involved in peroxisomal fatty acid beta-oxidation. It was first identified as a 17-beta-estradiol dehydrogenase . Peroxisomal beta-oxidation of fatty acids is catalyzed by 3 enzymes: acyl-CoA oxidase, the 'D-bifunctional enzyme, ' with enoyl-CoA-hydratase and D-3-hydroxyacyl-CoA dehydrogenase activity, and 3-ketoacyl-CoA thiolase. The D- and L-bifunctional proteins have different substrate specificities. The D-bifunctional protein catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids and also acts in shortening cholesterol for bile acid formation. In contrast, the L-specific bifunctional protein does not have the latter 2 activities.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminal of human HSD17B4, identical to the related rat and mouse sequences.
Form	Lyophilized
Specificity	Human, Mouse, Rat. No cross reactivity with other proteins.
Storage	2-8C. For long term -20C after reconstitution.
References	1. Green, V. L., Speirs, V., Landolt, A. M., Foy, P. M., Atkin, S. L.17-beta-hydroxysteroid dehydrogenase type 1, 2, 3, and 4 expression and enzyme activity in human anterior pituitary adenomas.J. Clin. Endocr. Metab. 84: 1340-1345, 1999. 2. Jiang, L. L., Miyazawa, S., Souri, M., Hashimoto, T.Structure of D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein.J. Biochem. 121: 364-369, 1997. 3.Leenders, F., Dolez, V., Begue, A., Moller, G., Gloeckner, J., de Launoit, Y., Adamski, J.Structure of the gene for the human 17-beta-hydroxysteroid dehydrogenase type IV.Mammalian Genome 9: 1036-1041, 1998.
Reconstitution	Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Purification	Immunogen affinity purified.
Contents	Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

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Menge: 100 ug

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