Anti-Coagulation Factor IX (F9)

Factor IX is one of the serine proteases (EC 3.4.21.22) of the coagulation system, it belongs to peptidase family S1. Deficiency of this protein causes hemophilia B. It was discovered after a young boy named Stephen Christmas was found to be lacking this exact factor, leading to hemophilia, in 1952. Factor IX is inactive unless activated by factor XIa (of the contact pathway) or factor VIIa (of the tissue factor pathway). When activated into factor IXa, in the presence of Ca2+, membrane phospholipids, and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa.Deficiency of factor IX causes Christmas disease (hemophilia B). Over 100 mutations of factor IX have been described, some cause no symptoms, but many lead to a significant bleeding disorder.

Western blotting: 1:100-400, Immunocytochemistry in formalin fixed cells: 1:100-500, Immunohistochemistry in formalin fixed frozen section: 1:100-500, Immunohistochemistry in paraffin section: 1:50-417

HEMB, FIX, GLA Domain, PTC, Anti Hemophilic Factor B, Christmas Factor, Plasma Thromboplastic Component, Christmas Disease, Hemophilia B

Mouse