Anti-Colony Stimulating Factor Receptor, Granulocyte (GCSFR)

The granulocyte colony-stimulating factor receptor (G-CSF-R) is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). The granulocyte colony-stimulating factor receptor is present on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. Th G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. Mutations in the intracellular part of this receptor are associated with certain types of leukemia.

Western blotting: 1:100-400, Immunocytochemistry in formalin fixed cells: 1:100-500, Immunohistochemistry in formalin fixed frozen section: 1:100-500, Immunohistochemistry in paraffin section: 1:50-417

G-CSFR, CSF3R, CD114, CSF3-R, GCSF-R

Human