Mouse Monoclonal Antibody to PDGFRß

Mouse IgG1

MW: 190kDa
Enterez GeneID: 5159
General Information: Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRß or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor a (PDGFRa) and PDGF receptor ß (PDGFRß). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Immunogen: Purified recombinant fragment of human PDGFRß expressed in E. Coli.
Size and Concentration: 100ug/1mg/ml
Supplied As: Lyophilized Powder from 100ul of Ascitic fluid containing 0.03% sodium azide.
Reconstitution and Storage: Reconstituted with 100ul sterile DI H2O, at stored at 4C or -20C for short or long term storage.
Applications: ELISA: 1 to 10000; WB: 1 to 500 - 1 to 2000
References: 1. Biochem Biophys Res Commun. 2005 Sep 9; 334(4):1198-205. ; 2. Brain Res Mol Brain Res. 2005 Aug 18; 138(2):236-43. ; 3. FASEB J. 2003 Jul; 17(10):1238-47.