Anti-Sonic Hedgehog Antibody

Q15465

Polyclonal

H, M, Rat

WB

Anti-Sonic Hedgehog antibody, ABO10556, IHC(P)IHC(P): Rat Brain Tissue

0.5-1 µg/ml

IHC

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity). .

Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.

Immunogen affinity purified.

At -20?C for one year. After r?Constitution, at 4?C for one month. It?Can also be aliquotted and stored frozen at -20?C for a longer time.Avoid repeated freezing and thawing.

Belongs to the hedgehog family.