Vergleich

Goat Anti-MAD4 / MXD4 Antibody

ArtNr ABC-AF1645a
Hersteller Abcepta
Menge 100 ug
Kategorie
Typ Antibody Primary
Applikationen WB, ELISA
Specific against other
Host Goat
ECLASS 10.1 32160702
ECLASS 11.0 32160702
UNSPSC 12352203
Similar products MXD4, MAD4, bHLHc12, Max dimerization protein 4, Max-associated protein 4, BHLHC12, Max dimerizer 4, Class C basic helix-loop-helix protein 12, Max-interacting transcriptional repressor MAD4
Lieferbar
Primary Accession
Q14582
Antigen Type
Synthetic Peptide
Application
WB, E
Bio Background
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.
Bio References
c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts. Marcotte R, et al. J Cell Biochem, 2005 Dec 1. PMID 16167342.
Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin. Pope SN, et al. J Steroid Biochem Mol Biol, 2005 Feb. PMID 15862967.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621.
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.
Human liver specific transcriptional factor TCP10L binds to MAD4. Jiang DJ, et al. J Biochem Mol Biol, 2004 Jul 31. PMID 15469726.
Clonality
Polyclonal
Gene ID
10608
Gene Name
MXD4
Subtitle
Peptide-affinity purified goat antibody
Reactivity
H
Legend image 1
AF1645a staining (0.5 µg/ml) of human kidney lysate (RIPA buffer, 35 µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Type image 1
WB
Other Accession
NP_006445; 10608;
Concentration (mg/ml)
100ug/200ul

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

Menge: 100 ug
Lieferbar: In stock
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