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Cyclin B1 (G2- & M-phase Cyclin) Antibody - With BSA and Azide

Cyclin B1 (G2- & M-phase Cyclin) Antibody - With BSA and Azide

ArtNr	ABC-AH12574-U0020
Hersteller	Abcepta
Menge	20 ug
Kategorie	Antibodies Primary Antibodies
Typ	Antibody Primary
Applikationen	FC, IF, IHC
Clon	CCNB1/1098
Specific against	other
Host	Mouse
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Similar products	CCNB1, CCNB, G2/mitotic-specific cyclin-B1
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Primary Accession	P14635
Application	IHC, IF, FC
Bio Background	It recognizes a protein of 55-62kDa, identified as cyclin B1. In mammals, cyclin B associates with inactive p34cdc2, which facilitates phosphorylation of p34cdc2 at aa 14Thr and 15Tyr. This maintains the inactive state until the end of G2-phase. The inactive cyclin B-p34cdc2 complex continues to accumulate in the cytoplasm until the completion of DNA synthesis, when Cdc25, a specific protein phosphatase, dephosphorylates aa 14Thr and 15Tyr of p34cdc2 rendering the complex active at the G2/M boundary. This mitotic kinase complex remains active until the metaphase/anaphase transition when cyclin B is degraded. This degradation process is ubiquitin-dependent and is necessary for the cell to exit mitosis. So, cyclin B-p34cdc2 plays a critical role in G2 to M transition.
Bio References	Galaktionov, K. and Beach D. 1991. Specific activation of Cdc25 tyrosine phosphatases by B type cyclins: Evidence for multiple roles of mitotic cyclins. Cell 67: 1181-1194
Clonality	Monoclonal
Gene ID	891
Gene Name	CCNB1
Subtitle	Mouse Monoclonal Antibody [Clone CCNB1/1098 ]
Reactivity	H, M
Legend image 1	Formalin-fixed, paraffin-embedded human Tonsil stained with Cyclin B1 Monoclonal Antibody (CCNB1/1098)
Type image 1	IHC
Legend image 2	Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with Cyclin B1 Monoclonal Antibody (CCNB1/1098)
Type image 2	IHC
Legend image 3	Formalin-fixed, paraffin-embedded human Endometrial Carcinoma stained with Cyclin B1 Monoclonal Antibody (CCNB1/1098)
Type image 3	IHC
Legend image 4	Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Cyclin B1 Monoclonal Antibody (CCNB1/1098)
Type image 4	IHC
Legend image 5	Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with Cyclin B1 Monoclonal Antibody (CCNB1/1098)
Type image 5	IHC
Other Accession	891, 23960
	Clone: CCNB1/1098

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Alle Produkte sind nur für Forschungszwecke bestimmt. Nicht für den menschlichen, tierärztlichen oder therapeutischen Gebrauch.

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ABC-AH12574-U0020-datasheet.pdf

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Menge: 20 ug

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