FFAR1 antibody - N-terminal region

O14842

G-protein coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose- stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (By similarity). Ligand binding leads to a conformation change that triggers signaling via G-proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway.

Polyclonal

FFAR1

H, M, Rat, Pig, B, Dog

WB

H, M, Rat, Pig, B, Dog

The immunogen for anti-FFAR1 antibody: synthetic peptide directed towards the N terminal of human FFAR1

300

NM_005303

FFA1R, GPCR40, GPR40