KEAP1 Antibody

ArtNr	ABC-AM1968b
Hersteller	Abcepta
Menge	400 ul
Kategorie	Oncology Antibodies By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cell Movement Cell Adhesion Adenocarcinoma Western Blot Primary Antibodies
Typ	Antibody Monoclonal
Applikationen	WB
Clon	297CT6.1.6
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgM Kappa
Citations	Dinkova-Kostova, A.T., et al. J. Biol. Chem. 285(44):33747-33755(2010) Kang, H.J., et al. J. Biol. Chem. 285(28):21258-21268(2010) Lau, A., et al. Mol. Cell. Biol. 30(13):3275-3285(2010) Copple, I.M., et al. J. Biol. Chem. 285(22):16782-16788(2010) Takahashi, T., et al. J Surg Oncol 101(6):500-506(2010)
NCBI	NP_036421.2,NP_987096.1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Kelch-like ECH-associated protein 1,Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19,KEAP1,INRF2,KIAA0132,KLHL19
Similar products	KEAP1, INRF2, KIAA0132, KLHL19, Kelch-like ECH-associated protein 1, Cytosolic inhibitor of Nrf2, Kelch-like protein 19, INrf2
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Manufacturer - Category	Primary Antibodies
Manufacturer - Targets	This KEAP1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 422-449 amino acids from human KEAP1.
Bio Background	This gene encodes a protein containing KELCH-1 likedomains, as well as a BTB/POZ domain. Kelch-like ECH-associatedprotein 1 interacts with NF-E2-related factor 2 in aredox-sensitive manner and the dissociation of the proteins in thecytoplasm is followed by transportation of NF-E2-related factor 2to the nucleus. This interaction results in the expression of thecatalytic subunit of gamma-glutamylcysteine synthetase. Twoalternatively spliced transcript variants encoding the same isoformhave been found for this gene.
Clonality	Monoclonal
Gene Name	KEAP1 {ECO:0000303\|PubMed:14585973, ECO:0000312\|HGNC:HGNC:23177}
Subtitle	Mouse Monoclonal Antibody (Mab)
Reactivity	H
Predicted Reactivity	Pig
Calculated Molecular Weight	69666
Antigen Source	HUMAN
Antigen Region	422-449
Formulation	Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Euglobin precipitation followed by dialysis against PBS.
Dilution	WB: 1:100
Antigen Type	Synthetic Peptide

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