ITGAE Antibody (C-term)

NP_002199.3

Integrins are heterodimeric integral membrane proteins
composed of an alpha chain and a beta chain. ITGAE encodes an
I-domain-containing alpha integrin that undergoes
post-translational cleavage in the extracellular domain, yielding
disulfide-linked heavy and light chains. In combination with the
beta 7 integrin, this protein forms the E-cadherin binding integrin
known as the human mucosal lymphocyte-1 antigen. This protein is
preferentially expressed in human intestinal intraepithelial
lymphocytes (IEL), and in addition to a role in adhesion, it may
serve as an accessory molecule for IEL activation. [provided by
RefSeq].

3682

H

1146-1173

This ITGAE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1146-1173 amino acids from the C-terminal region of human ITGAE.